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Cell lines offer the advantages of immortality and high reproducibility, facilitating long-term, continuous experimentation without needing to maintain low passage numbers

To view a copy of this licence, visit About this article Cite this article Schmidtbauer, M., Withycombe, J., Han, J

Vitamin B12 can be converted to coenzyme B12 in tissues, and as such is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine, a reaction which also requires folate

However, in states of activation, including oncogenesis, B cell activation depends on G6PD and PPP activity to mitigate oxidative stress (65), and the hypermetabolic leukocytes of acute B-cell leukemia are likewise more sensitive to oxidant stressors, such as dihydroartemisinin (66)